TD-165

TD-165 is a PROTAC-based cereblon (CRBN) degrader. TD-165 comprises a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group[1].

Product Specifications

CAS Number

[2305936-56-3]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

PROTACs

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/td-165.html

Purity

98.08

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C([C@H]1N(C([C@@H](NC(CCCCCCCCCCNC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5

Molecular Formula

C46H59N7O8S

Molecular Weight

870.07

Precautions

H315, H319

References & Citations

[1]Kim K, et al. Disordered region of cereblon is required for efficient degradation by proteolysis-targeting chimera.Sci Rep. 2019 Dec 23;9 (1) :19654.