ML346

ML346 is an activator of Hsp70 expression and HSF-1 activity, with an EC50 of 4.6 μM for Hsp70. ML346 restores protein folding in conformational disease models, without significant cytotoxicity or lack of specificity. ML346 induces specific increases in genes and protein effectors of the heat shock response (HSR), including chaperones such as Hsp70, Hsp40, and Hsp27[1].

Product Specifications

CAS Number

[100872-83-1]

UNSPSC

12352005

Hazard Statement

H315, H317, H318, H334, H335, H341, H361, H370, H413

Target

HSP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Neuroscience-Neurodegeneration

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ML346.html

Concentration

10mM

Purity

98.25

Solubility

DMSO : 12.5 mg/mL (ultrasonic)

Smiles

O=C1NC(/C(C(N1)=O)=C/C=C/C2=CC=C(OC)C=C2)=O

Molecular Formula

C14H12N2O4

Molecular Weight

272.26

Precautions

H315, H317, H318, H334, H335, H341, H361, H370, H413

References & Citations

[1]Calamini B, et al. ML346: A Novel Modulator of Proteostasis for Protein Conformational Diseases.Probe Reports from the NIH Molecular Libraries Program. Bethesda (MD) : National Center for Biotechnology Information (US) ; 2010-. 2012 Dec 17.|[2]Calamini B, et al. Small-molecule proteostasis regulators for protein conformational diseases. Nat Chem Biol. 2011 Dec 25;8 (2) :185-96.