Lipid U 105

Lipid U 105, an ionizable cationic lipid (pKa = 6.65), is employed in formulating lipid nanoparticles (LNPs) for delivering circular RNA both in vitro and in vivo. These LNPs, containing lipid U 105 and circular RNA for VEGF-A, enhance VEGF-A levels, boosting the proliferation and migration of human umbilical vein endothelial cells (HUVECs) . Moreover, applying these LNPs topically accelerates wound healing in diabetic mice on a high-fat and -sugar diet.