Senecionine

Senecionine (Senecionan-11,16-dione, 12-hydroxy-) is a pyrrolizidine alkaloid could be isolated from Senecio vulgaris. Senecionine decreases the activities of glutathione S-transferase, aminopyrine demethylase and arylhydrocarbon hydroxylase (AHH) [1][2][3].

Product Specifications

CAS Number

[130-01-8]

Product Name Alternative

Senecionan-11,16-dione, 12-hydroxy-; Aureine; Senecionin

UNSPSC

12352005

Hazard Statement

H300+H310+H330

Target

Others

Type

Natural Products

Related Pathways

Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Senecionine.html

Purity

99.48

Solubility

DMSO : 1.43 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1O[C@@]2([H])[C@]3([H])N(CC=C3COC([C@](C)(O)[C@H](C)C/C1=C/C)=O)CC2

Molecular Formula

C18H25NO5

Molecular Weight

335.39

Precautions

H300+H310+H330

References & Citations

[1]Wang C, et al. The comparative pharmacokinetics of two pyrrolizidine alkaloids, senecionine and adonifoline, and their main metabolites in rats after intravenous and oral administration by UPLC/ESIMS. Anal Bioanal Chem. 2011 Jul;401 (1) :275-87.|[2]Kakrani HK, et al. Effect of seneciphylline and senecionine on hepatic drug metabolizing enzymes in rats. J Ethnopharmacol. 1984 Dec;12 (3) :271-8.|[3]Tu ZB, et al. Identification of senecionine and senecionine N-oxide as antifertility constituents in Senecio vulgaris. J Pharm Sci. 1988 May;77 (5) :461-3.