Disorazol A
Disorazol A1 is a tubulin inhibitor with antifungal properties. It functions by inhibiting tubulin polymerization and disrupting microtubule formation, thereby blocking mitosis and arresting the cell cycle at the G2/M phase, which induces apoptosis. Disorazol A1 also inhibits L929 mouse fibroblasts with an IC50 value of 3 pm and causes accumulation of p53 protein in the nucleus. Disorazol A1 holds potential for cancer research.
Product Specifications
CAS Number
158181-47-6
Field of Research
Cell Biology, Infectious Disease & Virology, Signal Transduction
Smiles
C/C=C/[C@@H] (C (C) (C) [C@@H]1C/C=C\C=C/C=C\[C@@H] (CC2=NC (=CO2) C (=O) O[C@@H] (C/C=C\[C@@H]3[C@@H] (O3) /C=C\C=C/C4=NC (=CO4) C (=O) O1) C (C) (C) [C@H] (/C=C/C) O) OC) O
Molecular Formula
C43H54N2O10
Molecular Weight
758.896
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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