Chaetoglobosin E
Chaetoglobosin E is a ferroptosis inducer exhibiting significant cytotoxicity against the human tumor cell lines MDA-MB231 and A549, with IC50 values of 9.14 μM and 7.47 μM, respectively. It induces ferroptosis by downregulating GPX4 expression in A549 cells, leading to increased intracellular levels of Fe2+ (iron ions) and the lipid peroxidation product malondialdehyde (MDA), resulting in mitochondrial shrinkage and reduced or absent cristae. Chaetoglobosin E is applicable in cancer research.
Product Specifications
CAS Number
55945-74-9
Field of Research
Cell Biology
Smiles
O=C1[C@]23[C@] ([C@H] (CC=4C=5C (NC4) =CC=CC5) N1) (C (C) =C (C) [C@@H] (O) [C@@]2 (/C=C/C[C@H] (C) /C=C (\C) /C (=O) [C@@H] (O) CCC3=O) [H]) [H]
Molecular Formula
C32H38N2O5
Molecular Weight
530.654
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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