UK-370106

UK-370106 is a potent and highly selective MMP-3 (IC50 of 23 nM) and MMP-12 (IC50 of 42 nM) inhibitor with >1200-fold higher potency than MMP-1, MMP-2, MMP-9, and MMP-14, and about 100-fold than MMP-13 and MMP-8. UK-370106 potently inhibits cleavage of [3H]-fibronectin by MMP-3 (IC50 of 320 nM) and has little effect on keratinocyte migration in vitro[1][2].

Product Specifications

CAS Number

[230961-21-4]

UNSPSC

12352005

Target

MMP

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/uk-370106.html

Concentration

10mM

Purity

99.0

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

CC1=C(C2=CC=CC=C2)C=CC(CCC[C@H](CC(O)=O)C(N[C@@H](C(C)(C)C)C(N[C@@H](C3=CC=CC=C3)COC)=O)=O)=C1

Molecular Formula

C35H44N2O5

Molecular Weight

572.73

References & Citations

[1]Fray MJ, et al. A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic dermal ulcers. J Med Chem. 2003 Jul 31;46 (16) :3514-25.|[2]Whitlock GA, et al. A novel series of highly selective inhibitors of MMP-3. Bioorg Med Chem Lett. 2007 Dec 15;17 (24) :6750-3. Epub 2007 Oct 17.