AM-5308

AM-5308 is the inhibitor for KIF18A (IC50=47 nM) that inhibits KIF18A-mediated microtubule ATPase activity. AM-5308 activates mitotic checkpoints, regulates cell division processes, including chromosome segregation and spindle assembly. AM-5308 exhibits antitumor activity[1][2].

Product Specifications

CAS Number

[2410796-89-1]

UNSPSC

12352005

Target

Kinesin; Microtubule/Tubulin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/am-5308.html

Purity

99.15

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

C[C@@H](OCC1)CN1C2=NC(NC(C3=C(C=C(C=C3)NS(CCO)(=O)=O)N4CCC5(CC4)CC5)=O)=CC=C2

Molecular Formula

C26H35N5O5S

Molecular Weight

529.65

References & Citations

[1]Marc Noel PAYTON, et al. Kif18a inhibitors for treatment of neoplastic diseases. WO2021211549A1.|[2]Payton M, et al., Small-molecule inhibition of kinesin KIF18A reveals a mitotic vulnerability enriched in chromosomally unstable cancers. Nat Cancer. 2024 Jan;5 (1) :66-84.