AM-5308
AM-5308 is the inhibitor for KIF18A (IC50=47 nM) that inhibits KIF18A-mediated microtubule ATPase activity. AM-5308 activates mitotic checkpoints, regulates cell division processes, including chromosome segregation and spindle assembly. AM-5308 exhibits antitumor activity[1][2].
Product Specifications
CAS Number
2410796-89-1
UNSPSC
12352005
Target
Kinesin; Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/am-5308.html
Purity
99.15
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
C[C@@H](OCC1)CN1C2=NC(NC(C3=C(C=C(C=C3)NS(CCO)(=O)=O)N4CCC5(CC4)CC5)=O)=CC=C2
Molecular Formula
C26H35N5O5S
Molecular Weight
529.65
References & Citations
[1]Marc Noel PAYTON, et al. Kif18a inhibitors for treatment of neoplastic diseases. WO2021211549A1.|[2]Payton M, et al., Small-molecule inhibition of kinesin KIF18A reveals a mitotic vulnerability enriched in chromosomally unstable cancers. Nat Cancer. 2024 Jan;5 (1) :66-84.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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