PBT 1033

PBT 1033 (PBT 2) is an orally active copper/zinc ionophore. PBT 1033 restores cognition in mouse models of Alzheimer's disease (AD) . PB 1033 also has antibacterial activity against Gram-positive bacteria[1][2].

Product Specifications

CAS Number

[747408-78-2]

Product Name Alternative

PBT 2

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pbt-1033.html

Purity

99.51

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

ClC1=CC(Cl)=C(O)C2=C1C=CC(CN(C)C)=N2

Molecular Formula

C12H12Cl2N2O

Molecular Weight

271.15

Precautions

H302, H315, H319, H335

References & Citations

[1]Faux NG, et al. PBT2 rapidly improves cognition in Alzheimer's Disease: additional phase II analyses. J Alzheimers Dis. 2010;20 (2) :509-16. |[2]Harbison-Price N, et al. Multiple Bactericidal Mechanisms of the Zinc Ionophore PBT2. mSphere. 2020 Mar 18;5 (2) :e00157-20. |[3]Johanssen T, et al. PBT2 inhibits glutamate-induced excitotoxicity in neurons through metal-mediated preconditioning. Neurobiol Dis. 2015 Sep;81:176-85. |[4]Crouch PJ, et al. The Alzheimer's therapeutic PBT2 promotes amyloid-β degradation and GSK3 phosphorylation via a metal chaperone activity. J Neurochem. 2011 Oct;119 (1) :220-30. |[5]Adlard PA, et al. Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease. PLoS One. 2011 Mar 11;6 (3) :e17669.