SST0116CL1
Product Specifications
UNSPSC Description
SST0116CL1 is a HSP90 inhibitor (IC50: 0.21 μM). SST0116CL1 binds to the ATP binding pocket of Hsp90, and interferes with Hsp90 chaperone function thus resulting in client protein (EGFR, CDK4 and AKT) degradation. SST0116CL1 induces degradation of Her2 in BT-474 cell (IC50: 0.2 μM). SST0116CL1 has antiproliferative activity and inhibits tumor growth[1].
Target Antigen
Akt; CDK; EGFR; HSP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;JAK/STAT Signaling;Metabolic Enzyme/Protease;PI3K/Akt/mTOR;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sst0116cl1.html
Smiles
O=C(NCC)C1=NOC(C2=CC(C(C)C)=C(O)C=C2O)=C1NC(CCN3CCOCC3)=O.Cl
Molecular Weight
482.96
References & Citations
[1]Vesci L, et al. Preclinical antitumor activity of SST0116CL1: a novel heat shock protein 90 inhibitor. Int J Oncol. 2014 Oct;45(4):1421-9.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-164399/SST0116CL1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-164399/
Clinical Information
No Development Reported
CAS Number
1799802-29-1
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