Cipepofol
Product Specifications
Product Name Alternative
ACT-179811
UNSPSC Description
Cipepofol (Ciprofol), a novel 2,6-disubstituted phenol derivative, is a positive allosteric modulator and direct agonist of the GABAA receptor. Cipepofol can cause the central nerve inhibition and promote sleep based on the structural modification of Propofol (HY-B0649). Cipepofol can activate the sirtuin1 (Sirt1)/Nrf2 pathway. Cipepofol protects the heart against Isoproterenol (ISO; HY-B0468)-induced myocardial infarction by reducing cardiac oxidative stress, inflammatory response and cardiomyocyte apoptosis[1][2].
Target Antigen
Apoptosis; GABA Receptor; Keap1-Nrf2; Sirtuin
Type
Reference compound
Related Pathways
Apoptosis;Cell Cycle/DNA Damage;Epigenetics;Membrane Transporter/Ion Channel;Neuronal Signaling;NF-κB
Field of Research
Inflammation/Immunology; Neurological Disease; Cardiovascular Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/cipepofol.html
Purity
99.82
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C1=CC=CC([C@@H](C2CC2)C)=C1O)C
Molecular Weight
204.31
References & Citations
[1]Ming Lu, et al. Ciprofol: A Novel Alternative to Propofol in Clinical Intravenous Anesthesia? Biomed Res Int. 2023 Jan 19:2023:7443226.|[2]Yunzhao Yang, et al. Ciprofol attenuates the isoproterenol-induced oxidative damage, inflammatory response and cardiomyocyte apoptosis. Front Pharmacol. 2022 Nov 22:13:1037151.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-116152/Cipepofol-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-116152/Cipepofol-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
1637741-58-2
Available Sizes
Curated Selection
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