Balinatunfib
Balinatunfib (SAR-441566) is an orally active inhibitor of TNFR1 signaling. By binding to the central pocket of the soluble TNFα (sTNFα) trimer, Balinatunfib stabilizes an asymmetric conformation, blocking its binding to TNFR1 (without affecting TNFR2) and thus inhibiting downstream pathways. Balinatunfib has anti-inflammatory activity, and can be used in the study of autoimmune diseases[1][2].
Product Specifications
CAS Number
2248726-53-4
Product Name Alternative
SAR-441566; TNFα activity modulator 3
UNSPSC
12352005
Target
TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tnfα-activity-modulator-3.html
Concentration
10mM
Purity
98.40
Solubility
DMSO : 116.67 mg/mL (ultrasonic)
Smiles
FC(F)OC1=C(C(C2=O)=CC=C1)[C@](C[C@@]3([H])N2C)([H])N4C3=NC5=CC=C(C6=CN=C(C7(CCC7)N)N=C6)C=C45
Molecular Formula
C27H24F2N6O2
Molecular Weight
502.52
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Frequently Asked Questions
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