Balinatunfib

Balinatunfib (SAR-441566) is an orally active inhibitor of TNFR1 signaling. By binding to the central pocket of the soluble TNFα (sTNFα) trimer, Balinatunfib stabilizes an asymmetric conformation, blocking its binding to TNFR1 (without affecting TNFR2) and thus inhibiting downstream pathways. Balinatunfib has anti-inflammatory activity, and can be used in the study of autoimmune diseases[1][2].

Product Specifications

CAS Number

[2248726-53-4]

Product Name Alternative

SAR-441566; TNFα activity modulator 3

UNSPSC

12352005

Target

TNF Receptor

Type

Reference compound

Related Pathways

Apoptosis

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/tnfα-activity-modulator-3.html

Concentration

10mM

Purity

98.40

Solubility

DMSO : 116.67 mg/mL (ultrasonic)

Smiles

FC(F)OC1=C(C(C2=O)=CC=C1)[C@](C[C@@]3([H])N2C)([H])N4C3=NC5=CC=C(C6=CN=C(C7(CCC7)N)N=C6)C=C45

Molecular Formula

C27H24F2N6O2

Molecular Weight

502.52

References & Citations

[1]Nassr N, et al. First-in-Human Single and Multiple Ascending Dose Studies of Balinatunfib, a Small Molecule Inhibitor of TNFR1 Signaling in Healthy Participants. Clin Pharmacol Ther. 2025 Mar 30.|[2]Vugler A, et al. An orally available small molecule that targets soluble TNF to deliver anti-TNF biologic-like efficacy in rheumatoid arthritis. Front Pharmacol. 2022 Nov 16;13:1037983. doi: 10.3389/fphar.2022.1037983IF: 4.4 Q1 . Erratum in: Front Pharmacol. 2024 Oct 16;15:1479557.