KRA-533
KRA-533 is a potent KRAS agonist. KRA-533 binds to the GTP/GDP binding pocket in the KRAS protein to prevent GTP cleavage, resulting in the accumulation of constitutively active GTP-bound KRAS that triggers both apoptotic and autophagic cell death pathways in cancer cells.
Product Specifications
CAS Number
10161-87-2
Purity
>98% (HPLC)
Solubility
DMSO : 250 mg/mL (795.72 mM; ultraphonic; )
Molecular Formula
C13H16BrNO3
Molecular Weight
314.179
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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