TIP48/49-IN-1
TIP48/49-IN-1 (Compound B) is an orally active, specific RUVBL1/2 ATPase inhibitor, with an IC50 of 59 nM for purified RUVBL1/2. It disrupts the DNA replication process, causing S phase arrest, induces apoptosis, inhibits tumor growth, and enhances the radiosensitivity of non-small cell lung cancer cells (NSCLC) .
Product Specifications
CAS Number
1807337-58-1
Field of Research
Epigenetics & Chromatin, Pharmacology & Drug Discovery
Smiles
O (CC) C1=C (C=2OC (=NN2) [C@@H]3C[C@H] (C (NC=4C (=O) N (N (C) C4C) C5=CC=CC=C5) =O) CCC3) C=C (Cl) C=C1
Molecular Formula
C28H30ClN5O4
Molecular Weight
536.022
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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