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NF-κB/HIF-1α-IN-1

NF-κB/HIF-1α-IN-1 (compound 9c) effectively inhibits the NF-κB activation pathway and demonstrates selective antifibrotic activity. This compound exhibits no significant cytotoxicity in NCI tumor cell lines. In rat models, NF-κB/HIF-1α-IN-1 successfully ameliorates liver fibrosis, suppresses the expression levels of NF-κB and HIF-1α, and induces Nrf2.

Product Specifications

Field of Research

Epigenetics & Chromatin, Immunology & Inflammation, Metabolism Research, Signal Transduction

Molecular Formula

C24H27N7O4

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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