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VEN-02XX

VEN-02XX is an orally active NLRP3 inhibitor capable of penetrating the brain. It effectively suppresses the release of IL-1β and IL-18, with IC50 values of 0.3 and 0.28 μM, respectively. In the 5XFAD/Rubicon KO mouse model, VEN-02XX aids in restoring memory and cognition, inhibits microgliosis, and alleviates neuroinflammation and tau protein pathology. This compound is valuable for Alzheimer's disease (AD) research.

Product Specifications

Field of Research

Immunology & Inflammation

Smiles

CC (C) (O) CNC1=NN=C (C2=CC=C (Cl) C=C2C (F) (F) F) C3=C1C=NC=C3

Molecular Formula

C18H16ClF3N4O

Molecular Weight

396.79

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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