VEN-02XX
VEN-02XX is an orally active NLRP3 inhibitor capable of penetrating the brain. It effectively suppresses the release of IL-1β and IL-18, with IC50 values of 0.3 and 0.28 μM, respectively. In the 5XFAD/Rubicon KO mouse model, VEN-02XX aids in restoring memory and cognition, inhibits microgliosis, and alleviates neuroinflammation and tau protein pathology. This compound is valuable for Alzheimer's disease (AD) research.
Product Specifications
Field of Research
Immunology & Inflammation
Smiles
CC (C) (O) CNC1=NN=C (C2=CC=C (Cl) C=C2C (F) (F) F) C3=C1C=NC=C3
Molecular Formula
C18H16ClF3N4O
Molecular Weight
396.79
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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