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CDK9 degrader-1

CDK9degrader-1 is a selective CDK9 degrader (DC50: 0.4073 μM) . It recruits ATG101 to initiate the autophagy-lysosome pathway and forms autophagosomes by recruiting LC3, which then fuse with lysosomes to degrade CDK9 and its partner protein, Cyclin T1 (DC50: 1.215 μM) . CDK9degrader-1 induces caspase 3-mediated apoptosis and exhibits antitumor activity in a mouse HCT116 xenograft model.

Product Specifications

Field of Research

Cell Biology, Epigenetics & Chromatin

Smiles

ClC1=CC=CC (Cl) =C1C (NC2=CNN=C2C (NC3CCN (C (CCC (NC4=C (CCC5) C5=CC6=C4CCC6) =O) =O) CC3) =O) =O

Molecular Formula

C32H34Cl2N6O4

Molecular Weight

637.56

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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