MS2133
MS2133 is a DOT1L PROTAC degrader. It facilitates the ubiquitination and degradation of DOT1L in THP-1 and MV4-11 cells, with DC50 values of 56 nM and 25 nM, respectively, and reduces H3K79 methylation. MS2133 also inhibits the growth of MLL-r leukemia cells, demonstrating anticancer activity.
Product Specifications
Field of Research
Epigenetics & Chromatin, Pharmacology & Drug Discovery
Molecular Formula
C58H66ClF3N14O11S2
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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