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TRF1-TIN2 interaction-IN-1

TRF1-TIN2 interaction-IN-1 (Compound 40) is an inhibitor of the TRF1-TIN2 interaction. It binds to the TRFH domain of TRF1 (KD= 29 μM) and competitively inhibits the binding of the TIN2 peptide (IC50= 67 μM) . By occupying a hotspot at the TRF1-TIN2 interface, TRF1-TIN2 interaction-IN-1 disrupts the interaction between TRF1 and TIN2. This compound can remove TRF1 from the shelterin complex, making it useful for research on shelterin-related cancers.

Product Specifications

Field of Research

Molecular Biology

Smiles

OS (C1=CC=C (OCC2=CC (OC) =CC (OC) =C2) C3=C1C=CC=C3) (=O) =O

Molecular Formula

C19H18O6S

Molecular Weight

374.41

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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