5β-Cholestane-3α,7α,12α,25-tetrol
5β-Cholestane-3α,7α,12α,25-tetrol is a type of bile acid alcohol that activates the G protein-coupled bile acid receptor 1 (GPBAR1), also known as TGR5, in HEK293 cells that express the human receptor, at concentrations between 0.1 to 10 μM. In individuals with cerebrotendinous xanthomatosis (CTX), a progressive metabolic leukodystrophy, levels of this compound are elevated in the blood, feces, and bile.
Product Specifications
CAS Number
18866-87-0
Field of Research
Pharmacology & Drug Discovery
Smiles
O[C@H]1[C@]2 ([C@]3 ([C@@] (C) ([C@@] ([C@@H] (CCCC (C) (C) O) C) (CC3) [H]) [C@@H] (O) C[C@@]2 ([C@]4 (C) [C@] (C1) (C[C@H] (O) CC4) [H]) [H]) [H]) [H]
Molecular Formula
C27H48O4
Molecular Weight
436.67
Storage Conditions
-20°C
Notes
For research use only.
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