3′-Deoxy-3′-fluoroguanosine

3′-Deoxy-3′-fluoroguanosine exhibits antiviral activity against tick-borne encephalitis virus (TBEV), through interaction with NS5B RdRp of HCV, resulting in suppression of viral RNA synthesis by disruption of further extension of the replicating viral RNA[1].

Product Specifications

CAS Number

[123402-21-1]

UNSPSC

12352005

Hazard Statement

H302+H312+H332, H314

Target

DNA/RNA Synthesis; HCV

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/3-deoxy-3-fluoroguanosine.html

Purity

99.29

Solubility

DMSO : 20 mg/mL (ultrasonic)

Smiles

NC(NC1=O)=NC2=C1N=CN2[C@@H]3O[C@H](CO)[C@@H](F)[C@H]3O

Molecular Formula

C10H12FN5O4

Molecular Weight

285.24

Precautions

H302+H312+H332, H314

References & Citations

[1]Eyer L, et al., Broad-Spectrum Antiviral Activity of 3'-Deoxy-3'-Fluoroadenosine against Emerging Flaviviruses. Antimicrob Agents Chemother. 2021 Jan 20;65 (2) :e01522-20.