Exatecan Intermediate 1
Product Specifications
UNSPSC Description
Exatecan Intermediate 1 (compound 6) is an intermediate of Exatecan (DX-8951, HY-13631). Exatecan is an anticancer agent belonging to the class of camptothecin analogs. Exatecan can serve as the cytotoxic component of ADCs, disrupting tumor cell proliferation and division by interacting with DNA, thereby inhibiting tumor growth. Exatecan is primarily used for research of a variety of cancers including ovarian, lung and breast cancers[1][2][3].
Target Antigen
ADC Cytotoxin; Topoisomerase
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/exatecan-intermediate-1.html
Purity
99.99
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C1[C@](O)(CC)C(C=C23)=C(CO1)C(N3CCC2=O)=O
Molecular Weight
263.249
References & Citations
[1]Weng W, et al. Antibody-Exatecan Conjugates with a Novel Self-immolative Moiety Overcome Resistance in Colon and Lung Cancer. Cancer Discov. 2023 Apr 3;13(4):950-973. |[2]Zhang Hongwei, et al. Intermediate for synthesizing camptothecin derivatives using exatecan mesylate and its preparation method and application. China, CN111470998. 2020-07-31. |[3]Conilh L, et al. Exatecan Antibody Drug Conjugates Based on a Hydrophilic Polysarcosine Drug-Linker Platform. Pharmaceuticals (Basel). 2021 Mar 9;14(3):247.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-42487/Exatecan-Intermediate-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-42487/Exatecan-Intermediate-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
110351-94-5
Available Sizes
Curated Selection
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