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DBCO- (PEG2-VC-PAB-MMAE) 2

DBCO- (PEG2-VC-PAB-MMAE) 2 is made by MMAE conjugated to the cleavable DBCO- (PEG2-VC-PAB) 2 linker. Monomethyl auristatin E (MMAE), a potent tubulin inhibitor, is a toxin payload in antibody agent conjugate[1]. DBCO- (PEG2-VC-PAB-MMAE) 2 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

Product Specifications

CAS Number

2259318-55-1

UNSPSC

12352203

Target

Drug-Linker Conjugates for ADC

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dbco-peg2-vc-pab-mmae-2.html

Purity

99.21

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N1[C@](CCC1)([H])[C@H](OC)[C@@H](C)C(N[C@H](C)[C@H](C2=CC=CC=C2)O)=O)C[C@@H](OC)[C@@]([C@@H](C)CC)([H])N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC(C=C3)=CC=C3NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCN(CCOCCOCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC4=CC=C(COC(N(C)[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N(C)[C@]([C@@H](C)CC)([H])[C@H](OC)CC(N5[C@](CCC5)([H])[C@H](OC)[C@@H](C)C(N[C@H](C)[C@H](C6=CC=CC=C6)O)=O)=O)=O)=O)=O)C=C4)=O)=O)=O)C(CCC(N7C8=CC=CC=C8C#CC9=CC=CC=C9C7)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C149H224N22O32

Molecular Weight

2835.50

References & Citations

[1]Brian Lannutti, et al. Ror1 antibody immunoconjugates. WO2018237335A1.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

ADC Related

Clinical Information

No Development Reported

Isoform

Auristatin; Dual payloads

Available Sizes

Frequently Asked Questions

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