N6- (2-Hydroxyethyl) adenosine

N6- (2-Hydroxyethyl) adenosine is a purine nucleoside analog. N6- (2-Hydroxyethyl) adenosine inhibits NF-κB/Smad signaling pathway, exhibits anti-hyperglycemia, antioxidant, antitumor and anti-inflammatory and insecticidal activities. N6- (2-Hydroxyethyl) adenosine is orally active[1][2][3][4][5].

Product Specifications

CAS Number

[4338-48-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Autophagy; Insecticide; Mitochondrial Metabolism; NF-κB; Nucleoside Antimetabolite/Analog; Reactive Oxygen Species (ROS) ; SOD; TGF-beta/Smad

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others; Stem Cell/Wnt; TGF-beta/Smad

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/n6-2-hydroxyethyl-adenosine.html

Purity

99.85

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OCCNC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](CO)O3

Molecular Formula

C12H17N5O5

Molecular Weight

311.30

Precautions

H302, H315, H319, H335

References & Citations

[1]Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26 (6) :1490-1500.|[2]Wang X, et al., N6 - (2-hydroxyethyl) -adenosine from Cordyceps cicadae protects against diabetic kidney disease via alleviation of oxidative stress and inflammation. J Food Biochem. 2019 Feb;43 (2) :e12727.|[3]Zheng R, et al., N6- (2-Hydroxyethyl) Adenosine From Cordyceps cicadae Ameliorates Renal Interstitial Fibrosis and Prevents Inflammation via TGF-β1/Smad and NF-κB Signaling Pathway. Front Physiol. 2018 Sep 4;9:1229.|[4]Xie H, et al., N6- (2-hydroxyethyl) -Adenosine Induces Apoptosis via ER Stress and Autophagy of Gastric Carcinoma Cells In Vitro and In Vivo. Int J Mol Sci. 2020 Aug 13;21 (16) :5815.|[5]Fang M, et al., N6- (2-Hydroxyethyl) -Adenosine Exhibits Insecticidal Activity against Plutella xylostella via Adenosine Receptors. PLoS One. 2016 Sep 26;11 (9) :e0162859.