2'-O,4'-C-Methylenecytidine

2'-O,4'-C-Methylenecytidine (LNA-C (Bz) ) is a bicyclic nucleoside analogue with fixed N-type conformation. 2'-O,4'-C-Methylenecytidine can be used to synthesize oligonucleotides. 2'-O,4'-C-Methylenecytidine forms duplexes with complementary DNA and RNA strands[1][2].

Product Specifications

CAS Number

[206055-69-8]

Product Name Alternative

LNA-C (Bz)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Nucleoside Antimetabolite/Analog

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/2-o-4-c-methylenecytidine.html

Concentration

10mM

Purity

98.59

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC[C@]1(CO2)[C@@H](O)[C@@H]2[C@H](N3C=CC(N)=NC3=O)O1

Molecular Formula

C10H13N3O5

Molecular Weight

255.23

Precautions

H302, H315, H319, H335

References & Citations

[1]bicyclic nucleoside analogue, N-type conformation, synthesize oligonucleotides, duplexes|[2]Obika S, et, al. Stability and structural features of the duplexes containing nucleoside analogues with a fixed N-type conformation, 2′-O,4′-C-methyleneribonucleosides. Tetrahedron Letters. 1998 Jul 23; 39 (30) :5401-04.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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