Glaucocalyxin B
Glaucocalyxin B is an ent kaurane diterpenoid isolated from the Chinese traditional medicine Rabdosia japonica with anticancer and antitumor activity; decreases the growth of HL-60 cells with an IC50 of approximately 5.86 μM at 24 h.
Product Specifications
CAS Number
80508-81-2
UNSPSC
12352211
Target
Autophagy
Type
Natural Products
Related Pathways
Autophagy
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Glaucocalyxin-B.html
Purity
99.83
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1(C)C(CC[C@@]2(C)[C@@]3([H])[C@@]4(C(C([C@H](CC3)[C@H]4OC(C)=O)=C)=O)[C@H](O)C[C@]12[H])=O
Molecular Formula
C22H30O5
Molecular Weight
374.47
References & Citations
[1]Yang WH, et al. Glaucocalyxin A and B-induced cell death is related to GSH perturbation in human leukemia HL-60 cells. Anticancer Agents Med Chem. 2013 Oct;13 (8) :1280-90.|[2]Pan Y, et al. Glaucocalyxin B induces apoptosis and autophagy in human cervical cancer cells. Mol Med Rep. 2016 Aug;14 (2) :1751-5.|[3]Gan P, et al. Anti-inflammatory effects of glaucocalyxin B in microglia cells. J Pharmacol Sci. 2015 May;128 (1) :35-46.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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