C14-490
C14-490 is an ionizable cationic lipid (pKa= 5.94) utilized in the synthesis of lipid nanoparticles (LNPs) . These LNPs serve as a platform for subsequent gene editing studies in hematopoietic stem cells (HSCs) in utero. C14-490 LNPs encapsulate SpCas9 mRNA and TTR sgRNA, employing an optimized B5 formulation parameter, and are further enhanced by the surface attachment of CD45 antibody F (ab’) 2 fragments to create Systemically Targeted Editing Mechanism LNPs (STEM LNPs) .
Product Specifications
CAS Number
2639634-82-3
Field of Research
Metabolism Research, Signal Transduction
Smiles
OC (CN (CCN1CCN (CC1) CC (OCC) CN (CC (O) CCCCCCCCCCCC) CC (O) CCCCCCCCCCCC) CC (OCC) CN (CC (O) CCCCCCCCCCCC) CC (O) CCCCCCCCCCCC) CCCCCCCCCCCC
Molecular Formula
C86H177N5O7
Molecular Weight
1393.35
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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