Mal-amide-PEG8-Val-Cit-PAB-OH
Mal-amide-PEG8-Val-Cit-PAB-OH is a cleavable ADC linker, featuring a maleimide group, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB moiety. The maleimide group allows covalent bonding to free thiols on cysteine residues of proteins. The Val-Cit dipeptide is cleaved intracellularly by cathepsins to facilitate payload delivery via the PAB structure.
Product Specifications
CAS Number
2387738-43-2
Field of Research
Signal Transduction
Smiles
N (C ([C@@H] (NC ([C@@H] (NC (CCOCCOCCOCCOCCOCCOCCOCCOCCNC (CCN1C (=O) C=CC1=O) =O) =O) [C@@H] (C) C) =O) CCCNC (N) =O) =O) C2=CC=C (CO) C=C2
Molecular Formula
C44H71N7O16
Molecular Weight
954.072
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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