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Mal-amide-PEG8-Val-Cit-PAB-OH

Mal-amide-PEG8-Val-Cit-PAB-OH is a cleavable ADC linker, featuring a maleimide group, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB moiety. The maleimide group allows covalent bonding to free thiols on cysteine residues of proteins. The Val-Cit dipeptide is cleaved intracellularly by cathepsins to facilitate payload delivery via the PAB structure.

Product Specifications

CAS Number

2387738-43-2

Field of Research

Signal Transduction

Smiles

N (C ([C@@H] (NC ([C@@H] (NC (CCOCCOCCOCCOCCOCCOCCOCCOCCNC (CCN1C (=O) C=CC1=O) =O) =O) [C@@H] (C) C) =O) CCCNC (N) =O) =O) C2=CC=C (CO) C=C2

Molecular Formula

C44H71N7O16

Molecular Weight

954.072

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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