Fmoc-PEG2-Val-Cit-PAB-OH
Fmoc-PEG2-Val-Cit-PAB-OH is a cleavable ADC linker that features a Boc-protected amine, hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzyl alcohol on the PAB can be used for conjugating reactive groups (e.g., PNP) to attach a payload. The Fmoc protecting group is removable with piperidine, revealing a primary amine for amide bond formation in conjugation reactions. The Val-Cit-PAB segment is cleaved by cellular proteases to efficiently release the payload inside cells.
Product Specifications
CAS Number
2055024-59-2
Field of Research
Metabolism Research
Smiles
C (OC (NCCOCCOCCC (N[C@H] (C (N[C@H] (C (NC1=CC=C (CO) C=C1) =O) CCCNC (N) =O) =O) [C@@H] (C) C) =O) =O) C2C=3C (C=4C2=CC=CC4) =CC=CC3
Molecular Formula
C40H52N6O9
Molecular Weight
760.876
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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