Fmoc-PEG4-Val-Cit-PAB-OH
Fmoc-PEG4-Val-Cit-PAB-OH is an enzyme-cleavable ADC linker that incorporates a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzyl alcohol on PAB can be used to attach reactive groups (such as PNP) for drug payload conjugation. The Fmoc protecting group can be removed with piperidine to expose a primary amine, facilitating amide bond formation. Val-Cit-PAB is cleaved by cellular proteases to efficiently release the payload inside cells.
Product Specifications
CAS Number
2055024-58-1
Field of Research
Signal Transduction
Smiles
C (OC (NCCOCCOCCOCCOCCC (N[C@H] (C (N[C@H] (C (NC1=CC=C (CO) C=C1) =O) CCCNC (N) =O) =O) [C@H] (C) C) =O) =O) C2C=3C (C=4C2=CC=CC4) =CC=CC3
Molecular Formula
C44H60N6O11
Molecular Weight
848.981
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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