T-Boc-N-amido-PEG4-Val-Cit
T-Boc-N-amido-PEG4-Val-Cit is a protease-cleavable ADC linker, featuring a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit dipeptide. The Val-Cit dipeptide is susceptible to cleavage by cellular proteases and contains a free carboxylic acid that can couple with amines to form amides. The Boc group can be removed under acidic conditions to reveal a free primary amine, which is useful for various reactions, such as conjugation or reductive amination.
Product Specifications
CAS Number
2231240-82-5
Field of Research
Signal Transduction
Smiles
[C@H] (C (N[C@@H] (CCCNC (N) =O) C (O) =O) =O) (NC (CCOCCOCCOCCOCCNC (OC (C) (C) C) =O) =O) [C@@H] (C) C
Molecular Formula
C27H51N5O11
Molecular Weight
621.721
Storage Conditions
-20°C
Notes
For research use only.
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