SR-318

SR-318, a chemical probe, is a potent and highly selective p38 MAPK inhibitor with IC50s of 5 nM, 32 nM and 6.11 μM for p38α, p38β and p38α/β, respectively. SR-318 potently inhibits the TNF-α release in whole blood with an IC50 of 283 nM. SR-318 has anti-cancer and anti-inflammatory activity[1].

Product Specifications

CAS Number

[2413286-32-3]

UNSPSC

12352005

Target

P38 MAPK; TNF Receptor

Type

Reference compound

Related Pathways

Apoptosis; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/sr-318.html

Concentration

10mM

Purity

98.17

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(C1=C(N)N(C2=CC=CC=C2)N=C1)NCC3=CC=C(C(NCCCC4CCCCC4)=O)C=C3

Molecular Formula

C27H33N5O2

Molecular Weight

459.58

References & Citations

[1]Röhm S, et al. Fast Iterative Synthetic Approach toward Identification of Novel Highly Selective p38 MAP Kinase Inhibitors. J Med Chem. 2019 Dec 12;62 (23) :10757-10782.