GGTI-2418
Product Specifications
UNSPSC Description
GGTI-2418 is a highly potent, competitive, and selective geranylgeranyltransferase I (GGTase I) inhibitor. GGTI-2418 inhibits GGTase I and FTase activities with IC50s of 9.5 nM and 53 μM, respectively. GGTI-2418 also increases p27(Kip1) and induces significant regression of breast tumors[1].
Target Antigen
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ggti-2418.html
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
CC(C)C[C@@H](C(O)=O)NC(N1[C@@H](CC2=CC=CC=C2)C(N(CC3=C(C)N=CN3)CC1)=O)=O
Molecular Weight
441.52
References & Citations
[1]Kazi A, et al. Blockade of protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: implications for breast cancer therapy. Mol Cell Biol. 2009 Apr;29(8):2254-63.|[2]Kuchay S, et al. PTEN counteracts FBXL2 to promote IP3R3- and Ca<sup>2+</sup>-mediated apoptosis limiting tumour growth. Nature. 2017 Jun 22;546(7659):554-558.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-16231/GGTI-2418-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-16231/GGTI-2418-SDS-MedChemExpress.pdf
Clinical Information
Phase 1
CAS Number
501010-06-6
Available Sizes
Curated Selection
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