JNJ-42253432
JNJ-42253432 is a CNS-penetrant, high-affinity and orally active P2X7 antagonist, with pKi values of 9.1 and 7.9 for rat and human P2X7 channels, respectively[1].
Product Specifications
CAS Number
[1428327-35-8]
UNSPSC
12352005
Target
P2X Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/jnj-42253432.html
Purity
98.15
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NCC1(CCCCC1)N2CCN(CC2)C3=CC=CC=C3)C4=CC=CC5=C4CCN(C5)C
Molecular Formula
C28H38N4O
Molecular Weight
446.63
References & Citations
[1]Brian Lord, et al. Pharmacology of a novel central nervous system-penetrant P2X7 antagonist JNJ-42253432. J Pharmacol Exp Ther. 2014 Dec;351 (3) :628-41.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P2X7 Receptor
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
