BCAT-IN-1

BCAT-IN-1 is a potent, selective and orally active inhibitor of BCATm, with a pIC50 of 7.3. BCAT-IN-1 shows 100-fold selectivity for BCATm over BCATc (pIC50=5.4) . BCAT-IN-1 can be used for the research of metabolic diseases[1].

Product Specifications

CAS Number

[1875078-61-7]

UNSPSC

12352005

Target

Aminotransferases (Transaminases)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/bcat-in-1.html

Purity

98.06

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C2N([C@H]3C[C@@H](NC(C4=CC=C(Br)S4)=O)CCC3)C(C5=NC=CC=C5)=NC2=C1)NC

Molecular Formula

C25H24BrN5O2S

Molecular Weight

538.46

References & Citations

[1]Deng H, et, al. Discovery and Optimization of Potent, Selective, and in Vivo Efficacious 2-Aryl Benzimidazole BCATm Inhibitors. ACS Med Chem Lett. 2016 Feb 8;7 (4) :379-84.