BCAT-IN-1
BCAT-IN-1 is a potent, selective and orally active inhibitor of BCATm, with a pIC50 of 7.3. BCAT-IN-1 shows 100-fold selectivity for BCATm over BCATc (pIC50=5.4) . BCAT-IN-1 can be used for the research of metabolic diseases[1].
Product Specifications
CAS Number
[1875078-61-7]
UNSPSC
12352005
Target
Aminotransferases (Transaminases)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/bcat-in-1.html
Purity
98.06
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C2N([C@H]3C[C@@H](NC(C4=CC=C(Br)S4)=O)CCC3)C(C5=NC=CC=C5)=NC2=C1)NC
Molecular Formula
C25H24BrN5O2S
Molecular Weight
538.46
References & Citations
[1]Deng H, et, al. Discovery and Optimization of Potent, Selective, and in Vivo Efficacious 2-Aryl Benzimidazole BCATm Inhibitors. ACS Med Chem Lett. 2016 Feb 8;7 (4) :379-84.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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