ATG13 Rabbit pAb
Atg13 was identified as a constitutively expressed protein that was genetically linked to Atg1/Apg1, a protein kinase required for autophagy. Overexpression of Atg1 suppresses the defects in autophagy observed in Atg13 mutants. Autophagy requires a direct association between Atg1 and Atg13, and is inhibited by TOR-dependent phosphorylation of Atg13 under high-nutrient conditions.
Product Specifications
Background
Atg13 was identified as a constitutively expressed protein that was genetically linked to Atg1/Apg1, a protein kinase required for autophagy. Overexpression of Atg1 suppresses the defects in autophagy observed in Atg13 mutants. Autophagy requires a direct association between Atg1 and Atg13, and is inhibited by TOR-dependent phosphorylation of Atg13 under high-nutrient conditions.
Product Name Alternative
Autophagy-related protein 13
UniProt
O75143
Swiss Prot
O75143
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human ATG13 AA range: 182-232
Target
ATG13
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; WB
Concentration
1 mg/ml
Dilution
IHC-p1:50-200 , WB 1:1000-2000
Buffer
-20°C/1 year
Molecular Weight
72kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
72kD
Fragment
IgG
Subcellular Location
Cytoplasm, cytosol . Preautophagosomal structure . Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation. .
Other Product Names
Autophagy-related protein 13
Gene ID (Human)
9776
Available Sizes
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