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SARS-CoV-2 Mpro-IN-29

SARS-CoV-2 Mpro-IN-29 (Compound 7) is an inhibitor of the SARS-CoV-2 main protease (Mpro) with an IC50 of 310 nM and an EC50 of 0.5 μM in Vero cells. SARS-CoV-2 Mpro-IN-29 binds to the active site of Mpro, blocking the cleavage of viral polyproteins, showing significant antiviral activity and enhanced metabolic function. SARS-CoV-2 Mpro-IN-29 holds potential for research on SARS-CoV-2 antiviral agents[1].

Product Specifications

UNSPSC

12352005

Target

SARS-CoV; Virus Protease

Type

Reference compound

Related Pathways

Anti-infection

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/sars-cov-2-mpro-in-29.html

Smiles

O=C([C@@H](NC(C1=CC2=C(C=CC=C2OC)N1)=O)CC(C)C)N[C@@H](CC3=CSC=N3)C(S(=O)(O[Na])=O)(O)[H]

Molecular Formula

C22H27N4NaO7S2

Molecular Weight

546.59

References & Citations

[1]Feys JR, et al. Peptide Aldehydes Incorporating Thiazol-4-yl Alanine Are Potent In Vitro Inhibitors of SARS-CoV-2 Main Protease. ACS Med Chem Lett. 2024 Nov 3;15 (11) :2046-2052.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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