Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Tyrphostin A9

Tyrphostin A9, a PDGFR inhibitor, is a potent inducer of mitochondrial fission. Tyrphostin A9 emerged as the most potent and selective of 51 tyrosine kinase inhibitors tested against the TNF-induced respiratory burst. Tyrphostin A9 has anti-influenza virus activities.

Product Specifications

CAS Number

10537-47-0

Product Name Alternative

Tyrphostin 9; Malonoben

UNSPSC

12352005

Hazard Statement

H301+H311

Target

Influenza Virus; PDGFR; VEGFR

Type

Reference compound

Related Pathways

Anti-infection; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/tyrphostin-a9.html

Concentration

10mM

Purity

99.91

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

N#C/C(C#N)=C/C1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1

Molecular Formula

C18H22N2O

Molecular Weight

282.38

Precautions

H301+H311

References & Citations

[1]Park SJ, Park YJ, Shin JH, et al. A receptor tyrosine kinase inhibitor, Tyrphostin A9 induces cancer cell death through Drp1 dependent mitochondria fragmentation. Biochem Biophys Res Commun. 2011 May 13;408 (3) :465-70.|[2]Richard F. Loeser, Christopher B. Forsyth, Allen M. Samarel et al. Fibronectin Fragment Activation of Proline-rich Tyrosine Kinase PYK2 Mediates Integrin Signals Regulating Collagenase-3 Expression by Human Chondrocytes through a Protein Kinase C-dependent Pathway. The Journal of Biological Chemistry, 2003, 278, 24577-24585.|[3]Michele Fuortes, Maxine Melchior, Hyunsil Han, et al. Role of the tyrosine kinase pyk2 in the integrin-dependent activation of human neutrophils by TNF. J Clin Invest. 1999;104 (3) :327-335.|[4]Johan Thyberg . Tyrphostin A9 and wortmannin perturb the Golgi complex and block proliferation of vascular smooth muscle cells. European Journal of Cell Biology.1998,76 (1) : 33-42|[5]R Marhaba, F Mary, C Pelassy, et al. Tyrphostin A9 inhibits calcium release-dependent phosphorylations and calcium entry via calcium release-activated channel in Jurkat T cells. The Journal of Immunology. 1996,157 (4) : 1468-1473|[6]Kumar N, et al. Receptor tyrosine kinase inhibitors block multiple steps of influenza a virus replication. J Virol. 2011 Mar;85 (6) :2818-2

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

PP5 (PPP5C) Rabbit Polyclonal Antibody
AP05147PU-N 100 µg

PP5 (PPP5C) Rabbit Polyclonal Antibody

Sign In for Pricing
View Details
XFD647 C2 Maleimide
1895-AAT 1 mg

XFD647 C2 Maleimide

Sign In for Pricing
View Details
AGXT2L2 (PHYKPL) (NM_153373) Human Recombinant Protein
TP307667L 1 mg

AGXT2L2 (PHYKPL) (NM_153373) Human Recombinant Protein

Sign In for Pricing
View Details
2',6'-Dichloroacetanilide
TRC-D431615-500MG 500 mg

2',6'-Dichloroacetanilide

Sign In for Pricing
View Details
PD-L1 Polyclonal Antibody
E-AB-65810-01 60 µL

PD-L1 Polyclonal Antibody

Sign In for Pricing
View Details
PD-L1 Polyclonal Antibody
E-AB-65810-02 120 µL

PD-L1 Polyclonal Antibody

Sign In for Pricing
View Details