AX20017
AX20017 is a small-molecule protein kinase G (PknG) inhibitor with an IC50 of 0.39 μM.
Product Specifications
CAS Number
[329221-38-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/AX20017.html
Concentration
10mM
Purity
99.69
Solubility
DMSO : 130 mg/mL (ultrasonic)
Smiles
O=C(N)C1=C(NC(C2CC2)=O)SC3=C1CCCC3
Molecular Formula
C13H16N2O2S
Molecular Weight
264.34
Precautions
H302, H315, H319, H335
References & Citations
[1]Walburger A, et al. Protein kinase G from pathogenic mycobacteria promotes survival within macrophages. Science. 2004 Jun 18;304 (5678) :1800-4.|[2]Santhi N, et al. Insights from the molecular docking of withanolide derivatives to the target protein PknG from Mycobacterium tuberculosis. Bioinformation. 2011;7 (1) :1-4.|[3]Scherr N, et al. Structural basis for the specific inhibition of protein kinase G, a virulence factor of Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2007 Jul 17;104 (29) :12151-6.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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