MCU-i4

MCU-i4 blocks the IP3-dependent mitochondrial Ca2+-uptake, maintaining the gatekeeping role of their target[1][2].

Product Specifications

CAS Number

[371924-24-2]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Mitochondrial Metabolism

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/mcu-i4.html

Purity

99.87

Solubility

DMSO : 12.5 mg/mL (ultrasonic)

Smiles

O=C(C1=C(NC2=CC=C(N(CC)CC)C=C2)C3=CC(C)=CC=C3N=C1)OCC

Molecular Formula

C23H27N3O2

Molecular Weight

377.48

Precautions

H315, H319

References & Citations

[1]Giulia Di Marco, et al. A High-Throughput Screening Identifies MICU1 Targeting Compounds. Cell Rep. 2020 Feb 18;30 (7) :2321-2331.e6.|[2]Alessandro Rimessi, et al. Update on Calcium Signaling in Cystic Fibrosis Lung Disease. Front Pharmacol. 2021 Mar 11;12:581645.