Propylthiouracil

Propylthiouracil (6-n-Propylthiouracil), a thioamide antithyroid agent, is an orally active thyroperoxidase and type-1 deiodinase (DIO1) inhibitor. Propylthiouracil can be used for the Graves disease and hyperthyroidism research[1].

Product Specifications

CAS Number

[51-52-5]

Product Name Alternative

6-n-Propylthiouracil; 6-Propyl-2-thiouracil; PTU

UNSPSC

12352005

Hazard Statement

H302, H351

Target

Thyroid Hormone Receptor

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/Propylthiouracil.html

Purity

99.88

Solubility

DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL (ultrasonic)

Smiles

O=C(C=C(CCC)N1)NC1=S

Molecular Formula

C7H10N2OS

Molecular Weight

170.23

Precautions

H302, H351

References & Citations

[1]Lamis Chamas, et al. A Fine Regulation of the Hippocampal Thyroid Signalling Protects Hypothyroid Mice against Glial Cell Activation. Int J Mol Sci. 2022 Oct 8;23 (19) :11938.|[2]Utsana Puapermpoonsiri, et al. Synergistic effect of phospholipid-based liposomes and propylthiouracil on U-937 cell growth. J Liposome Res. 2005;15 (3-4) :215-27.