2,6-Dimethylquinoline

2,6-Dimethylquinoline, a nature constituent from the roots of Peucedantu praeruptorum, is a CYP1A2 inhibitor with an IC50 of 3.3 µM. 2,6-Dimethylquinoline also inhibits CYP2B6 activity with an IC50 of 480 µM[1][2][3].

Product Specifications

CAS Number

[877-43-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Cytochrome P450

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/2-6-dimethylquinoline.html

Purity

99.95

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1=CC2=C(C=C1)N=C(C)C=C2

Molecular Formula

C11H11N

Molecular Weight

157.22

Precautions

H302, H315, H319, H335

References & Citations

[1]Laura E Korhonen, et al. Predictive three-dimensional quantitative structure-activity relationship of cytochrome P450 1A2 inhibitors. J Med Chem. 2005 Jun 2;48 (11) :3808-15.|[2]L E Korhonen, et al. New potent and selective cytochrome P450 2B6 (CYP2B6) inhibitors based on three-dimensional quantitative structure-activity relationship (3D-QSAR) analysis. Br J Pharmacol. 2007 Apr;150 (7) :932-42.|[3]Cun Zhang, et al. Studies on chemical constituents from roots of Peucedanum praeruptorum II. Zhongguo Zhong Yao Za Zhi. 2006 Aug;31 (16) :1333-5.