E3 ligase Ligand 14
Product Specifications
UNSPSC Description
E3 ligase Ligand 14 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 14 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].
Target Antigen
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/e3-ligase-ligand-14.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H]1CCCC2=C1C=CC=C2)[C@H]3N(C[C@H](C3)OC4=CC=CC(O)=C4)C([C@@H](NC([C@H](C)N(C(OC(C)(C)C)=O)C)=O)C5CCCCC5)=O
Molecular Weight
676.84
References & Citations
[1]Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61(2):543-575.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-128811/E3-ligase-Ligand-14-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-128811/
Clinical Information
No Development Reported
CAS Number
2241489-43-8
Available Sizes
Curated Selection
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