AMG410
AMG410 is a potent, non-covalent dual-modality inhibitor targeting both GDP- and GTP-bound KRAS with low nanomolar affinity, showing selectivity over HRAS/NRAS. It is effective against multiple KRAS mutants (e.g., G12D, G12V) in vitro and induces tumor regression with reduced p-ERK in vivo cancer models.
Product Specifications
CAS Number
3040175-17-2
Product Name Alternative
AMG 410
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Purity
97.58% (May vary between batches)
Solubility
DMSO:4 mg/mL (6.1 mM)
Smiles
FC=1C=2C=3C4=C (C=C (Cl) C3CCCOC (=O) O[C@]5 (CN (C=6C (C1N=C (OC[C@@]78N (C[C@H] (F) C7) CCC8) N6) =CN2) CCOC5) [H]) NN=C4
Molecular Formula
C31H32ClF2N7O5
Molecular Weight
656.08
Storage Conditions
-20°C
Notes
For research use only.
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