AZD0022
AZD0022 is a selective, reversible, and orally active KRAS G12D inhibitor with high affinity for both GTP- and GDP-bound states, while sparing wild-type KRAS. It demonstrates anti-tumor activity in preclinical models of pancreatic ductal adenocarcinoma (PDAC) and non-small cell lung cancer (NSCLC), supporting its investigation for advanced solid tumors.
Product Specifications
CAS Number
2958627-18-2
Product Name Alternative
AZD 0022
Field of Research
Signal Transduction
Purity
98.73% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (5.37 mM) ; DMSO:80 mg/mL (130.16 mM)
Smiles
FC=1C=CC2=CC (N) =CC (C=3C (F) =CC=4C (=NC (=NC4N5CC6C=CC (N6) C5) OCC78N (CCC7) CC (F) C8) C3F) =C2C1C#C
Molecular Formula
C34H30F4N6O
Molecular Weight
614.64
Storage Conditions
-20°C
Notes
For research use only.
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